Activity of ceftaroline against Enterococcus faecium PBP5.

نویسندگان

  • Xavier Henry
  • Oliver Verlaine
  • Ana Amoroso
  • Jacques Coyette
  • Jean-Marie Frère
  • Bernard Joris
چکیده

The opportunistic human pathogen Enterococcus faecium overproduces the low-affinity PBP5. In clinical strains, mutations in PBP5 further reduce its acylation rate by β-lactams. Previous studies have reported that ceftaroline had poor inhibitory activity against β-lactam-resistant E. faecium strains. In this study, we show that ceftaroline exhibits killing activity against our laboratory-derived ampicillin-resistant E. faecium mutant that overproduces a wild-type PBP5 and that ceftaroline inactivates PBP5 much faster than benzylpenicillin and faster than ceftobiprole.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 57 12  شماره 

صفحات  -

تاریخ انتشار 2013